The present study was undertaken in order to investigate the effects of the commonly used anticonvulsant drugs on the thyroid hormones in epileptic children. Authors examined 79 patients(male 50,female 29) of five anticonavulsant-treated groups
who
valproic acid(VPA, n=26), carbamazepine(CBZ, n=16), diphenylhydantoin(DPH, n=13) and phenobarbital(PB, n=9) respectively, or a combination of these(COM, n=15) for the periods varying from 4 months to 6 years, and a control group of 40
children(male
30 ,
female 10).
@ES The results were summarized as follows:
@EN 1. The mean serum levels of T4. FT4 and T3 were significantly decreased in the groups treated with CBZ and COM, as compaired with those of the control, and those of T4 and FT4 were also significantly decreased in the group treated with DPH.
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